Human ITPRIPL1/CD3L1 Protein (CD3-HM2L1)
SKU: BTL-KB-P-00670 |
Host: Human |
Brand: Kactus Bio
Product Description
| Cat Number | CD3-HM2L1 |
|---|---|
| Category | Recombinant Protein |
| Pack Size | 100UG |
| Description | Recombinant Human ITPRIPL1/CD3L1 Protein is expressed from HEK293 with hFc (IgG1) tag at the C-terminus.It contains His25-Gly103. |
| Target | ITPRIPL1/CD3L1 |
| Host | Human |
| Purity | > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
| Scientific Background | Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 (ITPRIPL1), a single-pass type I membrane protein with uncharacterized functions, exhibits normal testis-enriched expression and widespread overexpression in various human cancers. ITPRIPL1 possesses a distinct ECD and is particularly prevalent in tumors exhibiting low or no PD-L1 expression. ITPRIPL1 functions as an inhibitory ligand of CD3ε, and its expression inhibits T cells in the tumor microenvironment. |
| Molecular Mass | The protein has a predicted MW of 35.24 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Bis-Tris PAGE result. |
| Sl Sequence | His25-Gly103 |
| Solubility | Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1mg/ml for 500μg or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
| Appearance | Lyophilized |
| Endotoxin Levels | Less than 1 EU per μg by the LAL method. |
| Expression System | HEK293 |
| Gene Id | Q6GPH6-1 |
| Amino Acid Sequence | Recombinant Human ITPRIPL1/CD3L1 Protein is expressed from HEK293 with hFc (IgG1) tag at the C-terminus.It contains His25-Gly103. |
| Storage | -20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| Note | The product is for research use only |
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