Product Description
| Cat Number | ASC12006 |
|---|---|
| Category | Primary Antibody |
| Pack Size | 100 µg |
| Description | CD4 Monoclonal Antibody: CD4 is a member of the immunoglobulin superfamily and is implicated as associative recognition element in MHC (Major Histocompatibility Complex) class II-restricted immune response. On T-lymphocytes, it defines the helper/inducer subset. The mature 55 kd CD4 protein consists of a 372 amino acid extracellular segment composed of four tandem immunoglobulin-like VJ regions. The CD4 molecule is a major receptor for human immunodeficiency virus (HIV), binding directly to the envelope glycoprotein gp120 on HIV, with the co-receptors being CCR5 or CXCR4. It has been shown that the V-like domains are critical for binding with HIV envelope gp120. |
| Applications | WB, IHC-P, IF, E |
| Target | Mouse monoclonal CD4 antibody was raised against a 193 amino acid recombinant protein from near the amino terminus of human CD4. |
| Clonality | Monoclonal |
| Gene | CD4 |
| Host | Mouse |
| Isotype | IgG1 |
| Form | Liquid |
| Buffer | CD4 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide. |
| Specie Reactivity | H, M, Rat |
| Reconstitution | CD4 monoclonal antibody can be stored at -20℃, stable for one year. |
| Image Legend | Immunofluorescence of Survivin in mouse brain tissue with Survivin Antibodyat 20 µg/mL. |
| References | Bowers K, Pitcher C, and Marsh M. CD4 : a co-receptor in the immune response and HIV infection. Int. J. Biochem. Cell Biol. 1997; 29 :871-5. Arthos J, Deen KC, Chaikin MA, et al. Identification of the residues in human CD4 critical for the binding of HIV. Cell 1989; 57:469-81. |
| Image Link | View Document |
| View Document | |
| Note | The product is for research use only |
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