Product Description
| Cat Number | AO1049a |
|---|---|
| Category | Primary Antibody |
| Pack Size | 100 µl |
| Description | Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from enteroendocrine L cells in response to ingested nutrients. The closely related peptides glucagon-like peptide (GLP-1) and glucagon have opposing effects on blood glucose. GLP-1 induces glucose-dependent insulin secretion in the pancreas, while glucagon stimulates gluconeogenesis and glycogenolysis in the liver. Glucagon is processed from a large precursor, proglucagon, in a tissue-specific manner in pancreatic alpha-cells. The identification of a hybrid peptide acting as both a GLP-1 agonist and a glucagon antagonist would provide a novel approach for the treatment of type 2 diabetes. |
| Applications | WB, E |
| Immunogen | Purified recombinant fragment of GLP expressed in E. Coli. |
| Clonality | Monoclonal |
| Clone | 1B7B4 |
| Gene | EHMT1 |
| Host | Mouse |
| Isotype | IgG1 |
| Image Legend | Figure 1: Western blot analysis using GLP mouse mAb against GLP recombinant protein. |
| References | 1. Clark Q. Pan, Joanne M. Buxton, Stephanie L. Yung, et al. J Biol Chem. 2006 Feb 27. 2.Michael F. Crutchlow, Jee-Young Nina Ham, et al. Int J Biochem Cell Biol. 2006;38(5-6):845-859. 3.Andrew Young Adv Pharmacol. 2005;52:151-71. |
| Image Link | View Document |
| View Document | |
| Note | The product is for research use only |
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