Product Description
| Cat Number | AN1241 |
|---|---|
| Category | Primary Antibody |
| Pack Size | 100 µl |
| Description | FOX3, also known as NeuN and hexaribonucleotide binding protein 3, is a neuron-specific RNA binding nuclear protein involved in the regulation of pre-mRNA alternative splicing (Kim et al., 2009). FOX3 dependent alternative splicing of Numb has recently been shown to play an important role in the progression of neuronal differentiation during vertebrate development (Kim et al., 2013). |
| Applications | WB, IF |
| Target | Recombinant protein taken from the N-terminus of human FOX3 expressed in and purified from E. Coli. |
| Immunogen Speice | human |
| Clonality | monoclonal |
| Clone | 1B7 |
| Gene | RBFOX3 |
| Specificity | Specific for the ~46/48k FOX3 protein doublet. |
| Synonyms | RNA binding protein fox-1 homolog 3, Fox-1 homolog C, RBFOX3 |
| Host | Mouse |
| Form | Affinity purified from tissue culture supernatant. 100 µl PBS + 10 mM sodium azide. |
| Specie Reactivity | H, M, Rat, B |
| References | Kim KK, Adelstein RS, Kawamoto S (2009) Identification of neuronal nuclei (NeuN) as Fox-3, a new member of the Fox-1 gene family of splicing factors. J Biol Chem. Nov 6; 284(45):31052-61. Kim KK, Nam J, Mukouyama YS, Kawamoto S. (2013) Rbfox3-regulated alternative splicing of Numb promotes neuronal differentiation during development. J Cell Biol. Feb 18;200(4):443-58 |
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| Note | The product is for research use only |
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