Human Siglec-3/CD33 Protein (SIG-HM203)
SKU: BTL-KB-P-03434 |
Host: Human |
Brand: Kactus Bio
Product Description
| Cat Number | SIG-HM203 |
|---|---|
| Category | Recombinant Protein |
| Pack Size | 100UG |
| Description | Recombinant Human Siglec-3/CD33 Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Asp18-His259. |
| Target | Siglec-3/CD33 |
| Host | Human |
| Purity | > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
| Scientific Background | CD33 (siglec-3), a well-known target in leukemia therapy, is an inhibitory sialoadhesin expressed in human leukocytes of the myeloid lineage and some lymphoid subsets, including NK cells. CD33 is the smallest siglec member. It preferentially binds to α2-6- and α2-3-sialylated glycans and strongly binds to sialylated ligands on leukemic cell lines. |
| Molecular Mass | The protein has a predicted MW of 53.6 kDa. Due to glycosylation, the protein migrates to 68-80 kDa based on Bis-Tris PAGE result. |
| Sl Sequence | Asp18-His259 |
| Solubility | Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1mg/ml for 500μg or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
| Appearance | Lyophilized |
| Endotoxin Levels | Less than 1 EU per μg by the LAL method. |
| Expression System | HEK293 |
| Gene Id | P20138-1 |
| Amino Acid Sequence | Recombinant Human Siglec-3/CD33 Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Asp18-His259. |
| Storage | -20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| View Document | |
| Note | The product is for research use only |
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