Recombinant Human IL-18 Protein (GMP Grade)
SKU: BTL-TB-MB-00549 |
Brand: Transgen Biotek
Product Description
| Cat Number | PM110-01 |
|---|---|
| Category | Molecular Biology Product |
| Pack Size | 10 μg |
| Description | Interleukin-18 (IL-18), also known as interferon-gamma-inducing factor, is a pro-inflammatory cytokine produced by various cell types, including hematopoietic and non-hematopoietic cells[1]. The primary function of IL-18 is to induce Th1 cells to secrete interferon-gamma (IFN-γ). This cytokine works synergistically with IL-12 to facilitate the differentiation of Th1 cells, which is critical for the host’ s defense mechanisms against intracellular bacteria, viruses, and fungi[2]. The combined action of IL-18 and IL-12 can activate cytotoxic T cells and natural killer cells to produce IFN-γ, potentially contributing to tumor immunity. The biological activity of IL-18 is not limited to these cells; it also plays a role in the development of Th17 cell responses. IL-18, in synergy with IL-23, can induce Th17 cells to secrete IL-17[3]. Storage at -20°C for two years. Shipping Dry ice (-70℃) |
| References | [1] Hu B, Ren J, Luo Y, Keith B, Young RM, Scholler J, Zhao Y, June CH. Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18. Cell Rep. 2017, 20(13):3025-3033. [2] Ihim SA, Abubakar SD, Zian Z, Sasaki T, Saffarioun M, Maleknia S, Azizi G. Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatment. Front Immunol. 2022, 13:919973. [3] Mi J, Liu Z, Pei S, Wu X, Zhao N, Jiang L, Zhang Z, Bai X. Mendelian randomization study for the roles of IL-18 and IL-1 receptor antagonist in the development of inflammatory bowel disease. Int Immunopharmacol. 2022, 110:109020. |
| Note | The product is for research use only |
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