Product Description
| Cat Number | PI-250 |
|---|---|
| Category | Peptide |
| Pack Size | 1 mg |
| Description | Pan-caspase inhibitor |
| Modification | Benzyloxycarbonyl (Z) at N terminal, Fluoromethylketone (FMK) at C terminal |
| Purity | >98% by TLC |
| Biomarker Target | Caspases |
| Sequence Three Letter Code | Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone |
| Molecular Formula | C22H30FN3O7 |
| Sl Sequence | Z-VAD-FMK |
| Solubility | Soluble to 10 mg/mL in DMSO |
| Appearance | White lyophilised solid |
| Storage | Store dry, dark and frozen |
| References |
Slee et al (1996) Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Biochem.J. 315 21 PMID: 8670109Ilangovan et al (2003) Inhibition of apoptosis by Z-VAD-fmk in SMN-depleted S2 cells. J. Biol. Chem. 278(33) 30993 PMID: 12783893Simmons et al (2009) Pretreatment with pancaspase inhibitor (Z-VAD-FMK) delays but does not prevent intraperitoneal heat-killed group B Streptococcus-induced preterm delivery in a pregnant mouse model. Infect. Dis. Obstet. Gynecol. 2009 749432 PMID: 20069051 Related areas_x000D_ All peptides >All caspase modulators >All cancer research categories > |
| Note | The product is for research use only |
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