Product Description
| Cat Number | PI-240 |
|---|---|
| Category | Peptide |
| Pack Size | 10 mg |
| Description | Deubiquitinase (DUB) inhibitor |
| Purity | >98% by HPLC |
| Biomarker Target | Deubiquitinating enzymes |
| Sequence Three Letter Code | (2E)€‹-3-€‹(6-€‹bromo-€‹2-€‹pyridinyl)€‹-€‹2-€‹cyano-€‹N-€‹[1S-€‹phenylbutyl]€‹-2-€‹propenamide |
| Molecular Formula | C19H18BrN3O |
| Sl Sequence | (2E)€‹-3-€‹(6-€‹bromo-€‹2-€‹pyridinyl)€‹-€‹2-€‹cyano-€‹N-€‹[1S-€‹phenylbutyl]€‹-2-€‹propenamide |
| Solubility | Soluble in DMSO and ethanol |
| Appearance | White solid |
| Storage | Store desiccated, frozen and in the dark |
| References |
Bartholomeusz et al (2007) Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells. 109(8) 3470 PMID: 17202319Bartholomeusz et al (2007) Degrasyn activates proteasomal-dependent degradation of c-Myc. Cancer Res. 67(8) 3912 PMID: 17440106Kapuria et al (2010) Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis. Cancer Res. 70(22) 9265 PMID: 21045142 Related areasAll small molecules >All deubiquitinating enzyme modulators >All cancer research categories > |
| Note | The product is for research use only |
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