Human NKp30/NCR3/CD337 Protein (NKP-HM230)
SKU: BTL-KB-P-03047 |
Host: Human |
Brand: Kactus Bio
Product Description
| Cat Number | NKP-HM230 |
|---|---|
| Category | Recombinant Protein |
| Pack Size | 100UG |
| Description | Recombinant Human NKp30/NCR3/CD337 Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Leu19-Thr138. |
| Target | NKp30/NCR3/CD337 |
| Host | Human |
| Purity | > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
| Scientific Background | NKp30, along with NKp44 and NKp46, constitute a group of receptors termed "Natural Cytotoxicity Receptors". These receptors play a major role in triggering NK-mediated killing of most tumor cells lines.NKp30 stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation. |
| Molecular Mass | The protein has a predicted MW of 39.8 kDa. Due to glycosylation, the protein migrates to 53-60 kDa based on Bis-Tris PAGE result. |
| Sl Sequence | Leu19-Thr138 |
| Solubility | Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1mg/ml for 500μg or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
| Appearance | Lyophilized |
| Endotoxin Levels | Less than 1 EU per ug by the LAL method. |
| Expression System | HEK293 |
| Gene Id | AAH52582 |
| Amino Acid Sequence | Recombinant Human NKp30/NCR3/CD337 Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Leu19-Thr138. |
| Storage | -20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| View Document | |
| Note | The product is for research use only |
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