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U0126

SKU: BTL-IB-P-00405 | Brand: Isca Biochemical
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Product Description
Cat Number KS-340
Category Peptide
Pack Size 5 mg
Description MAPK inhibitor
Purity 99% by HPLC
Biomarker Target Kinases
Sequence Three Letter Code 1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene
Molecular Formula C18H16N6S2
Solubility Soluble in DMSO up to 200 mg/ml
Appearance White solid
Storage Store dry, frozen and in the dark
References Favata et al (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem. 273(29) 18623 PMID: 9660836Duncia et al (1998) MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products. Bioorg Med Chem Lett. 8(20) 2839 PMID: 9873633Pricola (2009) Interleukin-6 maintains bone marrow-derived mesenchymal stem cell stemness by an ERK1/2-dependent mechanism. J Cell Biochem. 2009 108(3) 577 PMID: 19650110Kinehara et al (2013) Protein kinase C regulates human pluripotent stem cell self-renewal. PLoS One 8(1) e54122 PMID: 23349801You et al (2022) U0126: Not only a MAPK kinase inhibitor. Front Pharmacol. 13 927083 PMID: 36091807
Related areas All small molecules >All kinase modulators >All cancer research categories >All stem cell research categories >
Note The product is for research use only
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