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Staurosporine

SKU: BTL-IB-P-00361 | Brand: Isca Biochemical

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Product Description

Cat Number	KS-320
Category	Peptide
Pack Size	1 mg
Description	Broad spectrum kinase inhibitor
Purity	>98% by tlc
Biomarker Target	Kinases,Receptor tyrosine kinases
Sequence Three Letter Code	[9S-(9α,10β,11β,13α)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
Molecular Formula	C28H26N4O3
Solubility	Soluble in DMSO to 25 mg/ml
Appearance	Off white to pale yellow solid
Storage	Store dry, frozen and in the dark
References	Omura (1977) A new alkaloid AM-2282 OF Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization. J Antibiot (Tokyo) 30(4) 275 PMID: 863788RÃ¼egg and Burgess (1989) Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases. Trends Pharmacol Sci. 10(6) 218 PMID: 2672462Lewis et al (2018) Staurosporine Increases Lentiviral Vector Transduction Efficiency of Human Hematopoietic Stem and Progenitor Cells. Mol Ther Methods Clin Dev. 9 313 PMID: 30038935Malsy et al (2019) Staurosporine induces apoptosis in pancreatic carcinoma cells PaTu 8988t and Panc-1 via the intrinsic signaling pathway. Eur J Med Res. 24(1) 5 PMID: 30686270Ye et al (2020) Nuclear MYH9-induced CTNNB1 transcription, targeted by staurosporin, promotes gastric cancer cell anoikis resistance and metastasis. Theranostics 10(17) 7545 PMID: 32685004 Related areas All small molecules >All kinase modulators >All receptor tyrosine kinase modulators >All cancer research categories >All stem cell research categories >
Note	The product is for research use only

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