Product Description
| Cat Number | HX206026 |
|---|---|
| Category | Biosimilar |
| Pack Size | 100 ug |
| Description | MEDI3185haspicomolarbindingaffinitytohumanCXCR4andexhibitsnosignificantbindingtootherchemokinereceptorssuchasCCR4orCXCR3.InvitrostudiesdemonstratedthatMEDI3185inhibitedtumorcellmigration,blockedSDF-1inducedtumorcellsignalingandinducedapoptosisoftumorcells.TheMEDI3185epitopecomprisestheentireECL2sequence,lacksanyso-called'hot-spot'andisremarkablyresistanttomutations.ThestructureofMEDI3185variabledomainswasmodeled,andsuggestedaβ-strand/β-strandinteractionbetweenMEDI3185CDR3HandCXCR4ECL2,resultingindirectsterichindrancewithCXCR4ligandSDF-1. |
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| Target | Stromalcell-derivedfactor1receptor,LCR1,HM89,LPS-associatedprotein3,LAP-3,CXC-R4,CXCR-4,SDF-1receptor,CD184,NPYRL,LESTR,Fusin,FB22,C-X-Cchemokinereceptortype4,CXCR4,Lipopolysaccharide-associatedprotein3,Leukocyte-derivedseventransmembranedomainreceptor |
| Clonality | Monoclonal |
| Host | Human |
| Concentration | 1mg/ml |
| Isotype | IgG1 |
| Form | Liquid |
| Purity | >95% as determined by SDS-PAGE. |
| Specie Reactivity | Human |
| Storage | 0.01M PBS, pH7.4. |
| Note | The product is for research use only |
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