Product Description
| Cat Number | HB782116 |
|---|---|
| Category | Biosimilar |
| Pack Size | 100 ug |
| Description | TheFDAhasgrantedanorphandrugdesignationtosotigalimab(APX005M)asapotentialtherapeuticoptionforpatientswithsofttissuesarcoma,accordingtoannouncementfromApexigenInc.,thedrugdeveloper. Anovel,humanizedmonoclonalantibody,sotigalimabwasdesignedstimulateantitumorimmuneresponseandtotargetCD40,whichisakeyco-stimulatoryreceptorthatservestoactivateinnateandadaptiveimmunesystems.WhensotigalimabbindstoCD40onantigen-presentingcells,itinducesamultifacetedimmuneresponsethatbringsseveralcomponentsoftheimmunesystemtogethertoattackthecancer. |
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| Target | Tumornecrosisfactorreceptorsuperfamilymember5,B-cellsurfaceantigenCD40,Bp50,CD40Lreceptor,TNFRSF5,CDw40,CD40 |
| Clonality | Monoclonal |
| Synonyms | APX005M,APX-005,APX-005-M,APX-005M,CAS:2305607-45-6 |
| Host | Humanized |
| Concentration | 1.7mg/ml |
| Isotype | IgG1-Kappa |
| Form | Liquid |
| Purity | >95% as determined by SDS-PAGE. |
| Specie Reactivity | Human |
| Storage | 0.01M PBS, pH7.4. |
| Note | The product is for research use only |
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