Product Description
| Cat Number | CON021 |
|---|---|
| Category | Peptide |
| Pack Size | 0.1 mg |
| Description | µ-conotoxin CnIIIC is a conopeptide that has been isolated from the venom of the marine cone snail Conus consors. µ-conotoxin CnIIIC has been described to exhibit a myorelaxing effect through specific blockade of the skeletal muscle Nav1.4 channels (IC50 = 1.4 nM). µ-conotoxin CnIIIC also appears to block Nav1.2 channels (1 µM) and mildly Nav1.7. In contrast, Nav1.5 and Nav1.8 are insensitive to the action of the toxin. µ-conotoxin CnIIIC is also described to block the α3β2 nicotinic acetylcholine receptor (IC50= 450 nM) and to lesser extents the α7 and α4β2 subtypes and completely inhibits twitch tension in isolated mouse hemidiaphragms (IC50 = 150 nM). This peptide is a valuable tools to study Nav1.4 channels. |
| C Ter | NH2 |
| Disulfide Bonds | Cys3-Cys15; Cys4-Cys21; Cys10-Cys22 |
| Note | The product is for research use only |
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