Product Description
| Cat Number | 12PTX001 |
|---|---|
| Category | Peptide |
| Pack Size | 0.1 mg |
| Description | Protoxin I (ProTx-I; β-theraphotoxin-Tp1a) is a toxin that was originally isolated from the venom of Thrixopelma pruriens (Peruvian green velvet tarantula). This toxin reversibly inhibits the tetrodotoxin (TTX)-resistant channel Nav1.8(IC50 = 27 nM) and Nav1.2, Nav1.5 and Nav1.7 with IC50 values between 50 and 100 nM. Furthermore, ProTx-I shifts the voltage dependence activity of T-type Cav3.1 channels (IC50= 50 nM) without affecting the voltage dependence of inactivation. ProTx-I is a valuable tool to discriminate between Cav3.1 and Cav3.2 |
| C Ter | OH |
| Disulfide Bonds | Cys2-Cys16; Cys9-Cys21; Cys15-Cys28 |
| Note | The product is for research use only |
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