Product Description
| Cat Number | 12HTX001 |
|---|---|
| Category | Peptide |
| Pack Size | 0.1 mg |
| Description | Hainantoxin-IV (HNTX-IV) is a peptide that was originally isolated from the venom of the Chinese bird spider Ornithoctonus hainana Liang (Selenocosmia hainana Liang). It has been reported that this peptide is a potent antagonist of tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels (VGSCs). Hainantoxin-IV binds to TTX-S with an IC50value of 34 nM in adult rat dorsal root ganglion (DRG) neurons. Tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels are not affected by Hainantoxin-IV. It probably interacts with the site 1 through a mechanism quite similar to that of TTX without affecting the activation and inactivation kinetics. |
| C Ter | NH2 |
| Disulfide Bonds | Cys2-Cys17; Cys9-Cys24; ; Cys16-Cys31 |
| Note | The product is for research use only |
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