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Anti-Tyrosine Hydroxylase Antibody Purified

By: Team BTL Biotechno Labs Pvt. Ltd.

TH is the rate-limiting enzyme in the synthesis of the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine and is responsible for converting L-tyrosine to L-dopa. The synthesis of catecholamines is regulated by the interaction of TH with its cofactor, tetrahydrobiopterin (BH4), and the substrates L-tyrosine and molecular oxygen. In humans, four TH mRNA splice variants (hTH1–hTH4) have been isolated, while subprimate species rely on a single form of TH. It is known that the hTH1-hTH4 variants are identical in their catalytic domain but differ in their N-terminal regulatory domains. Importantly, LNC1 reacts with the catalytic domain of TH and thus with all four isoforms of human TH. The role of TH in the synthesis of catecholamine neurotransmitters suggests a connection between the enzyme and a number of neuropathogenic diseases characterized by irregular catecholamine levels, such as Parkinson's disease, schizophrenia, and dystonia, as well as a variety of cardiovascular diseases.

We, BTL Biotechno Labs Pvt. Ltd., a distributor of Antibodies Inc. in India, provide their Anti-Tyrosine Hydroxylase Antibody (Purified) having specificity to human, mouse, rat, zebrafish, chicken, monkey, lizard, and vole to support research in neurodegenerative disorders, particularly Parkinson’s disease. The antibody has applications in IHC, IP, and WB and is purified from PC12 cells.