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Protein Construction: A DNA sequence encoding the rat Ctse (AAH62002.1) (Met1-Pro398) was expressed with a polyhistidine tag at the C-terminus. Fusion Tag: C-His Expressed Host: HEK293 Cells Stability & StorageLyophilized proteins are stable for up to 12 months when stored at -20 to -80?C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20? for 3 months. Formulation: Lyophilized from sterile 12.5 mM MES, 75 mM NaCl, 50 % glycerol, pH 6.5 Background: Cathepsin E Protein (CTSE Protein) is a member of the peptidase C1 family that is a gastric aspartic protease that functions as a disulfide-linked homodimer. Cathepsin E Protein (CTSE Protein) is predominantly present in the cells of immune system and is frequently implicated in antigen processing via the MHC class? pathway which however does not appear to be involved in the digestion of dietary protein. The protein has a specificity similar to that of pepsin and pepsin. Cathepsin E Protein (CTSE Protein) is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach and also been found in more than half of the gastric cancers. It appears, therefore, to be an oncofetal antigen.